Anyone had NO medication work?

I'm asking this for my husband, who has been diagnosed with inattentive ADD.  He's trialed strattera, ritalin, concerta, adderall, adderall xr, vyvanse, focalin, daytrana and wellbutrin.  None of them had ANY beneficial effect other than the vyvanse having a barely discernable positive effect.  He experienced most of the bad side effects of every med; increased BP and heart rate, anxiety, panic attacks, big crashes after it wears off, etc.  

Any idea why meds seem to have no effect other than major side effects for him?  Anyone else experienced this, and were you finally able to find something that worked?  Thanks : )