Concerta making things worse!

My husband has been diagnosed with dysthymia and lymbic ADD. He's been taking Wellbutrin for about 6 weeks and it's really helped. He started taking Concerta last week and went back to how he was before the Wellbutrin or worse. He's VERY irritable, unpredictable, angry, has a short temper, etc. Has this happened to anyone else? He's stopped taking it and is going to try to get an earlier apointment with his Dr. (she had scheduled one for 3 weeks)